Test Subject 675 was born Arthur Grahams. He was a cryokinetic and serial killer. The Agency captured him in 2004. Following several escape attempts, the last of which was very nearly successful, Alpha authorized extreme measures. The Agency's Sigma section had theorized that psychic powers might be enhanced by the removal of part of the frontal lobe but had, for obvious ethical reasons, been unable to test this theory.

Given that the Agency couldn't contain Grahams and his power prevented them from putting him into cryo-storage, Alpha reasoned, they had only two choices; to kill him or to make him a test subject. In Alpha's own words; "I can not, in good conscience, ignore such an opportunity.". Grahams became Test Subject 675.